Flagyl is an antimicrobial and antiprotozoal drug with antibacterial activity for local gynecological administration. It is produced in forms of powder (solution for intravenous infusion solution), suspension for oral administration, tablets, vaginal tablets, coated tablets and vaginal suppositories. It is considered one of the most common examples of 5-nitroimidazoles.
- Pharmacological effect and general characteristics
The key component of Flagyl is metronidazole. It shows potent activity against Trichomonas vaginalis, Giardia lamblia (Lamblia intestinalis), Entamoeba histolytica; obligate anaerobes (spore and asporogenous) - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., Peptococcus spp., Sensitive strains of Eubacterium spp.). Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole. The medicament is used for local treatment of nonspecific vaginitis, Trichomonas vaginitis and prevention of anaerobic infections after surgical interventions on the abdominal and pelvic organs. It is necessary to continue treatment of the patient even in case of complete absence of symptoms and negative laboratory tests results. The maximum recommended duration of administration consists of 10 days. There should be no more than 2-3 Flagyl treatment courses in a year. If symptoms persist after completion of the course, it is necessary to re-diagnose (including bacterial inoculation and sensitivity test to antibiotics) and prescribe an appropriate treatment. It is necessary to control blood formula with prolonged use of metronidazole. Click here to buy generic Flagyl online now – it's safe, fast and reliable!
- Side effects and warnings
During the treatment there might occur local reactions: cervicitis or vaginitis caused by Candida spp. (vaginal itching, thick white mucous discharge from the vagina, odorless or with a faint odor); reactions in the digestive system: nausea, metallic taste in the mouth, dry mouth, glossitis, anorexia, epigastric pain, vomiting and diarrhea; allergic reactions: urticarial, pruritus. Urine staining in red-brown color due to the presence of water-soluble pigment formed from the metabolism of metronidazole is a rare case.
Flagyl administration is not recommended in case of blood diseases, organic central nervous system, pregnancy, lactation (breastfeeding), hypersensitivity to metronidazole or other nitroimidazole derivatives.
Since the simultaneous reception of metronidazole with alcohol can have an effect similar to disulfiram (a burning sensation, vomiting, tachycardia), patients should be warned that during treatment with Flagyl they should not drink alcoholic beverages or medications containing alcohol. It is necessary to carefully weigh pros and cons for the long-term drug usage and avoid its prolonged use if strict indications are absent.
- Impact on the ability to drive and engaging in other potentially hazardous activities
Given the profile of side effects (dizziness, blurred vision, and others) it is advised to refrain from driving and other potentially hazardous activities that require high concentration and quick psychomotor reactions.
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